Acid-Catalyzed Oxygen-18 Labeling of Peptides
نویسندگان
چکیده
منابع مشابه
Protease- and acid-catalyzed labeling workflows employing (18)O-enriched water.
Stable isotopes are essential tools in biological mass spectrometry. Historically, (18)O-stable isotopes have been extensively used to study the catalytic mechanisms of proteolytic enzymes(1-3). With the advent of mass spectrometry-based proteomics, the enzymatically-catalyzed incorporation of (18)O-atoms from stable isotopically enriched water has become a popular method to quantitatively comp...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2009
ISSN: 0003-2700,1520-6882
DOI: 10.1021/ac802484d